BNMI is now MITOVASC!
MITOVASC was founded from the association of several groups, including the former BNMI, sharing a common scientific goal, which is to provide a better understanding of the interaction between the small arteries controlling blood flow supply and the mitochondria controlling cell metabolism.
The scientific rationale is based upon the following facts:
1) vascular disorders appear often and early in many mitochondrial diseases such as MELAS (Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes), which is characterized by cerebrovascular disorders with NO insufficiency,
2) mitochondrial disorders appear early in both healthy and diseased vascular ageing,
3) both mitochondrial and vascular disorders play a key role in most common “metabolic” disorders including hypertension, diabetes, dyslipidemia,
4) mitochondria bioenergetic and dynamics appear to play a key role in the control of vascular tone and structure as suggested by recent observations.
Thus, we develop joint projects in the 2 main areas of the unit, cardiovascular and mitochondrial pathophysiology, in order to promote innovative results and development of new therapeutic targets.
The 2 main topics of the unit are divided into several tasks involving clinical and fundamental research. In order to strengthen translational research in the unit, we have founded the MitoVasc Institute, allowing better exchanges with MDs from the University Hospital of Angers. This institute favours medical practitioners to interact and get involve with our research unit.
The research strategy developed by the unit is based on a “bedside to bench to bedside” program. Clinical observations and investigations on preclinical models reproducing human diseases lead to hypotheses, which are then investigated in vitro, taking into consideration the interplay between mitochondria and blood vessels functioning.
Practically, the unit is made up of 2 teams:
- Team 1 led by Guy Lenaers and working on mitochondrial pathophysiology (MITOLAB)
- Team 2 led by Daniel Henrion and working on cardiovascular pathophysiology (CARME)
In order to improve interactions between teams, we have organized the technological support of the unit into several platforms. These platforms also provide scientific and technological support to other teams outside MITOVASC (see our collaborations).
"The aqueous buds extract of Eucalyptus neutralizes the main enzymatic acti...
« La dynamique mitochondriale par approche métabolomique et lipidomique »
"Effet cardioprotecteur de la colchicine à la phase aiguë de l'infarctus du...
L'impact de l'hétéroplasmie mitochondriale sur le métabolisme du glutamate ...
« Rôle du système immunitaire dans la relation artério-veineuse normale et ...
Mitochondrial Fusion and Vascular Effects: Role of OPA1 in hypertension and...
"Signalisation Purinergique Vasculaire – Régulation et Rôle de la Nucléosid...
Vascular dysfunction and environmental conditions in humans and animal expe...
UMR CNRS 6015 - UMR INSERM 1083
Faculté de Médecine
2 rue Haute de Reculée
49045 Angers cedex
Phone : +33241735845
Fax : +33241735895
Head of Department :
Dr Daniel Henrion (daniel.henrion @ univ-angers.fr)
Phone : +33241735878
Secretary of Institute :
Emmanuelle Maire (emmanuelle.maire @ univ-angers.fr)
Phone : +33241735845
Assistant of Prevention :
A (emmanuelle.maire @ univ-angers.fr)nne-Laure Guihot
Phone : +33241735953
COFO (continuing education):
Phone : +33241735873