Welcome on BNMI
The laboratory has a long history of research on vascular tone in resistance arteries and especially on pressure-mediated myogenic tone and flow (shear stress)-mediated dilation and remodelling. This vascular mechanotransduction involves local neuroeffector systems such as the renin-angiotensin system and the purinergic system, both involve in physiological response as well as in vascular diseases. The laboratory also investigates mitochondria bioenergetics and dynamics. Indeed, disorders in mitochondria function induce neurological and neurovascular disorders. Furthermore, changes in mitochondria bioenergetics and dynamics are also involved in cardiovascular and metabolic disorders, both affecting a growing part of the population.
The basic research is performed in association with the teams involved in clinical research in the University Hospital of Angers.
Over the past few years, we have investigated the age-related changes in resistance arteries tone and remodelling and associated with the main risk factors affecting the population; hypertension, obesity and diabetes. These risk factors affecting vascular homeostasis involve changes in mitochondrial function leading to excessive oxidative stress and vascular dysfunction. In contrast, “protective” factors, such as estrogens, protect the vascular endothelium, at least in part, through their regulatory effect on mitochondria. Thus, we now investigate endothelium dysfunction in aging, focusing on mitochondrial bioenergetics and dynamics. Among the main risk factors involved in vascular aging we investigate the consequences of a chronic stress and the role of adrenal chromaffin cells and thyroid hormones, which greatly influence vascular homeostasis and mitochondrial bioenergetics. We also investigate the epigenetic changes affecting vascular tone in offspring from mothers submitted to risk factors.
In Vitro Effects of the Endocrine Disruptor p,p'DDT on Human Follitropin Re...
Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone.
The angiotensin II type 2 receptor activates flow-mediated outward remodeli...
Les GPCR: de nouvelles cibles des perturbateurs endocriniens?
UMR CNRS 6214 - UMR INSERM 1083
Faculté de Médecine
2 rue Haute de Reculée
49045 Angers cedex
Phone : +33241735845
Fax : +33241735895
Head of Department :
Dr Daniel Henrion (daniel.henrion @ univ-angers.fr)
Phone : +33241735878
Secretary of Institute :
Emmanuelle Maire (emmanuelle.maire @ univ-angers.fr)
Phone : +33241735845
Assistant of Prevention :
A (emmanuelle.maire @ univ-angers.fr)nne-Laure Guihot
Phone : +33241735953
COFO (continuing education):
Phone : +33241735873