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Biologie neuroVasculaire et mitochondriale intégrée


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    The laboratory has a long history of research on vascular tone in resistance arteries and especially on pressure-mediated myogenic tone and flow (shear stress)-mediated dilation and remodelling. This vascular mechanotransduction involves local neuroeffector systems such as the renin-angiotensin system and the purinergic system, both involve in physiological response as well as in vascular diseases. The laboratory also investigates mitochondria bioenergetics and dynamics. Indeed, disorders in mitochondria function induce neurological and neurovascular disorders. Furthermore, changes in mitochondria bioenergetics and dynamics are also involved in cardiovascular and metabolic disorders, both affecting a growing part of the population.

    The basic research is performed in association with the teams involved in clinical research in the University Hospital of Angers.

    Over the past few years, we have investigated the age-related changes in resistance arteries tone and remodelling and associated with the main risk factors affecting the population; hypertension, obesity and diabetes. These risk factors affecting vascular homeostasis involve changes in mitochondrial function leading to excessive oxidative stress and vascular dysfunction. In contrast, “protective” factors, such as estrogens, protect the vascular endothelium, at least in part, through their regulatory effect on mitochondria. Thus, we now investigate endothelium dysfunction in aging, focusing on mitochondrial bioenergetics and dynamics. Among the main risk factors involved in vascular aging we investigate the consequences of a chronic stress and the role of adrenal chromaffin cells and thyroid hormones, which greatly influence vascular homeostasis and mitochondrial bioenergetics. We also investigate the epigenetic changes affecting vascular tone in offspring from mothers submitted to risk factors.

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    BNMI

    UMR CNRS 6214 - UMR INSERM 1083
    Faculté de Médecine
    2 rue Haute  de Reculée
    49045 Angers cedex

    Phone : +33241735845
    Fax : +33241735895

     

    Head of Department :

    Dr Daniel Henrion (daniel.henrion @ univ-angers.fr)
    Phone : +33241735878

     

    Secretary of Institute :

    Emmanuelle Maire (emmanuelle.maire @ univ-angers.fr)
    Phone : +33241735845

    Assistant of Prevention :

    A (emmanuelle.maire @ univ-angers.fr)nne-Laure Guihot
    Phone : +33241735953

    COFO (continuing education):

    Marie Chabbert
    Phone : +33241735873

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